HNRNPF Antibody

說明書

中文名稱：

HNRNPF兔多克隆抗體
貨號：

CSB-PA002946
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using hnRNP F Polyclonal Antibody

Western Blot analysis of various cells using hnRNP F Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P52597
基因名：

HNRNPF
別名：

Heterogeneous nuclear ribonucleoprotein F antibody; hnRNP F antibody; HnRNP F protein antibody; Hnrnpf antibody; HNRPF antibody; HNRPF_HUMAN antibody; mcs94 1 antibody; MGC110997 antibody; N-terminally processed antibody; Nucleolin like protein antibody; Nucleolin like protein mcs94 1 antibody; Nucleolin-like protein mcs94-1 antibody; OK/SW-cl.23 antibody; OTTHUMP00000019482 antibody; OTTHUMP00000043413 antibody; OTTHUMP00000043414 antibody; Ribonucleoprotein F antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human hnRNP F.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
基因功能參考文獻：
1. hnRNP H/F are important for maintenance and differentiation of embryonic stem cells and that this at least in part reflects a switch in TCF3 alternative splicing that leads to repression of CDH1/E-cadherin. PMID: 30115631
2. Results from a study on gene expression variability markers in early-stage human embryos shows that HNRNPF is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
3. heterogeneous nuclear ribonucleoprotein F (hnRNPF) regulates G-quadruplex-associated alternative splicing across the transcriptome. PMID: 29269483
4. Simulation results demonstrate that the RNA binding domain qRRM2 of hnRNP F binds strongly with G-tract RNA, but any mutation of the G-tract leads to a drastic reduction of the binding free energy. PMID: 29050934
5. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys. PMID: 28424160
6. hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. PMID: 24978456
7. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959
8. The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA. PMID: 20526337
9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
10. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function. PMID: 20308327
11. high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis PMID: 16424007
12. The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA. PMID: 16885237
13. hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo PMID: 19244236
14. Shows that hnRNPF regulates the 3' end cleavage reaction. PMID: 11158309
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亞細胞定位：

Nucleus, nucleoplasm.
組織特異性：

Expressed ubiquitously.
數據庫鏈接：

HGNC: 5039

OMIM: 601037

KEGG: hsa:3185

STRING: 9606.ENSP00000338477

UniGene: Hs.712955

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