HNRNPF Antibody, Biotin conjugated

說明書

中文名稱：

HNRNPF兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA010608LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HNRNPF Polyclonal antibody
Uniprot No.：

P52597
基因名：

HNRNPF
別名：

Heterogeneous nuclear ribonucleoprotein F antibody; hnRNP F antibody; HnRNP F protein antibody; Hnrnpf antibody; HNRPF antibody; HNRPF_HUMAN antibody; mcs94 1 antibody; MGC110997 antibody; N-terminally processed antibody; Nucleolin like protein antibody; Nucleolin like protein mcs94 1 antibody; Nucleolin-like protein mcs94-1 antibody; OK/SW-cl.23 antibody; OTTHUMP00000019482 antibody; OTTHUMP00000043413 antibody; OTTHUMP00000043414 antibody; Ribonucleoprotein F antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Heterogeneous nuclear ribonucleoprotein F protein (186-336AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
基因功能參考文獻：
1. hnRNP H/F are important for maintenance and differentiation of embryonic stem cells and that this at least in part reflects a switch in TCF3 alternative splicing that leads to repression of CDH1/E-cadherin. PMID: 30115631
2. Results from a study on gene expression variability markers in early-stage human embryos shows that HNRNPF is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
3. heterogeneous nuclear ribonucleoprotein F (hnRNPF) regulates G-quadruplex-associated alternative splicing across the transcriptome. PMID: 29269483
4. Simulation results demonstrate that the RNA binding domain qRRM2 of hnRNP F binds strongly with G-tract RNA, but any mutation of the G-tract leads to a drastic reduction of the binding free energy. PMID: 29050934
5. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys. PMID: 28424160
6. hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. PMID: 24978456
7. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959
8. The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA. PMID: 20526337
9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
10. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function. PMID: 20308327
11. high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis PMID: 16424007
12. The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA. PMID: 16885237
13. hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo PMID: 19244236
14. Shows that hnRNPF regulates the 3' end cleavage reaction. PMID: 11158309
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亞細胞定位：

Nucleus, nucleoplasm.
組織特異性：

Expressed ubiquitously.
數據庫鏈接：

HGNC: 5039

OMIM: 601037

KEGG: hsa:3185

STRING: 9606.ENSP00000338477

UniGene: Hs.712955

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