HLA-DOA Antibody

說明書

中文名稱：

HLA-DOA兔多克隆抗體
貨號：

CSB-PA356784ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA356784ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA356784ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HLA-DOA Polyclonal antibody
Uniprot No.：

P06340
基因名：

HLA-DOA
別名：

HLA-DOA antibody; HLA-DNA antibody; HLA-DZAHLA class II histocompatibility antigen antibody; DO alpha chain antibody; MHC DN-alpha antibody; MHC DZ alpha antibody; MHC class II antigen DOA antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human HLA class II histocompatibility antigen, DO alpha chain protein (26-135AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
基因功能參考文獻：
1. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID: 27486778
2. significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID: 25758996
3. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
4. HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID: 24530695
5. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID: 24384427
6. results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID: 23222639
7. analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID: 22733780
8. HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
9. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID: 15265882
10. These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID: 15817706
11. four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID: 16101837
12. minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID: 18639552
13. HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID: 19458622
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亞細胞定位：

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
蛋白家族：

MHC class II family
數據庫鏈接：

HGNC: 4936

OMIM: 142930

KEGG: hsa:3111

STRING: 9606.ENSP00000229829

UniGene: Hs.631991

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