HLA-DOA Antibody
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中文名稱：HLA-DOA兔多克隆抗體
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貨號：CSB-PA002934
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規格：￥1090
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圖片：
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Western Blot analysis of COLO205 cells using HLA-DOα Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：HLA-DOA antibody; HLA-DNA antibody; HLA-DZAHLA class II histocompatibility antigen antibody; DO alpha chain antibody; MHC DN-alpha antibody; MHC DZ alpha antibody; MHC class II antigen DOA antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human HLA-DOα.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
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基因功能參考文獻：
- Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID: 27486778
- significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID: 25758996
- TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
- HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID: 24530695
- HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID: 24384427
- results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID: 23222639
- analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID: 22733780
- HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
- In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID: 15265882
- These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID: 15817706
- four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID: 16101837
- minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID: 18639552
- HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID: 19458622
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亞細胞定位：Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
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蛋白家族：MHC class II family
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數據庫鏈接：
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