HECW2 Antibody
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中文名稱：HECW2兔多克隆抗體
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貨號：CSB-PA040086
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of 3T3 cells using NEDL2 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：HECW2
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別名：C2 and WW domain-containing protein 2 antibody; E3 ubiquitin protein ligase HECW2 antibody; E3 ubiquitin-protein ligase HECW2 antibody; HECT antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 antibody; Hecw2 antibody; HECW2_HUMAN antibody; KIAA130 antibody; KIAA1301 antibody; NEDD4 like E3 ubiquitin protein ligase 2 antibody; NEDD4 Related E3 Ubiquitin Ligase antibody; NEDD4-like E3 ubiquitin-protein ligase 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human NEDL2.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.
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基因功能參考文獻：
- Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation. PMID: 29753763
- HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability. PMID: 27498087
- HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans. PMID: 27389779
- This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified. PMID: 27334371
- Low HECW2 expression is associated with cervical cancer. PMID: 25156441
- NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition PMID: 24163370
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相關(guān)疾?。?/div>Neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL)亞細胞定位：Cytoplasm. Cytoplasm, cytoskeleton, spindle.組織特異性：Predominantly expressed in adult brain, lung and heart.數(shù)據(jù)庫鏈接：
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