HECW2 Antibody, Biotin conjugated
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中文名稱：HECW2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA889188LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HECW2 Polyclonal antibody
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Uniprot No.：
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基因名：HECW2
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別名：C2 and WW domain-containing protein 2 antibody; E3 ubiquitin protein ligase HECW2 antibody; E3 ubiquitin-protein ligase HECW2 antibody; HECT antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 antibody; Hecw2 antibody; HECW2_HUMAN antibody; KIAA130 antibody; KIAA1301 antibody; NEDD4 like E3 ubiquitin protein ligase 2 antibody; NEDD4 Related E3 Ubiquitin Ligase antibody; NEDD4-like E3 ubiquitin-protein ligase 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human E3 ubiquitin-protein ligase HECW2 protein (495-641AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.
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基因功能參考文獻：
- Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation. PMID: 29753763
- HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability. PMID: 27498087
- HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans. PMID: 27389779
- This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified. PMID: 27334371
- Low HECW2 expression is associated with cervical cancer. PMID: 25156441
- NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition PMID: 24163370
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相關疾病：Neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL)
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亞細胞定位：Cytoplasm. Cytoplasm, cytoskeleton, spindle.
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組織特異性：Predominantly expressed in adult brain, lung and heart.
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數據庫鏈接：
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