Guca2b Antibody

中文名稱：

Guca2b兔多克隆抗體
貨號：

CSB-PA010048LA01MO
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Guca2b Polyclonal antibody
Uniprot No.：

O09051
基因名：

Guca2b
別名：

Guca2b antibody; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin antibody; UGN)] antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Guanylate cyclase activator 2B protein (22-106AA)
免疫原種屬：

Mus musculus (Mouse)

標記方式：

Non-conjugated

本頁面中的產品，Guca2b Antibody (CSB-PA010048LA01MO)，的標記方式是Non-conjugated。對于Guca2b Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA010048LB01MO	Guca2b Antibody, HRP conjugated	ELISA
FITC	CSB-PA010048LC01MO	Guca2b Antibody, FITC conjugated
Biotin	CSB-PA010048LD01MO	Guca2b Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
基因功能參考文獻：
1. In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
2. UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
3. findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
4. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
5. Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406
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亞細胞定位：

Secreted.
蛋白家族：

Guanylin family
組織特異性：

Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
數據庫鏈接：

KEGG: mmu:14916

STRING: 10090.ENSMUSP00000043203

UniGene: Mm.278

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