Mouse guanylate cyclase activator 2B (GUCA2B) ELISA kit
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中文名稱：小鼠鳥苷酸環(huán)化酶激活劑2B(GUCA2B)酶聯(lián)免疫試劑盒
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貨號：CSB-EL010048MO
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：小鼠鳥苷酸環(huán)化酶激活劑2B(GUCA2B)酶聯(lián)免疫試劑盒（CSB-EL010048MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的GUCA2B含量。GUCA2B，又稱尿鳥苷酸，是一種候選的腸鈉尿激素，負責調(diào)節(jié)腸道與腎臟之間的鈉和水平衡。研究顯示，GUCA2B基因敲除小鼠血壓升高，提示其可能與原發(fā)性高血壓相關(guān)。其研究機制涉及激活鳥苷酸環(huán)化酶活性，參與cGMP介導的信號傳導。試劑盒檢測范圍為62.5 ng/ml-4000ng/ml，靈敏度為15.6 ng/ml。可應(yīng)用于胃腸動力研究、腎臟生理學實驗、代謝性疾病模型構(gòu)建等科研領(lǐng)域，為探究GUCA2B在消化系統(tǒng)、泌尿系統(tǒng)相關(guān)分子機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：Guca2b ELISA Kit; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin ELISA Kit; UGN)] ELISA Kit
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縮寫：GUCA2B
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：62.5 ng/ml-4000ng/ml
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靈敏度：15.6 ng/ml
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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數(shù)據(jù)處理：
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貨期：3-5 working days
產(chǎn)品評價
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靶點詳情
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最新研究進展：GUCA2B（小鼠鳥苷酸環(huán)化酶激活劑2B）是一種胃腸道分泌物，主要由腸道細胞產(chǎn)生，可通過糞便等渠道排出體外。近年來的研究發(fā)現(xiàn)，GUCA2B具有重要的生物學功能，可通過多種途徑參與胃腸道生理過程的調(diào)節(jié)，如促進腸道蠕動、抗炎作用、維護腸道屏障功能等。此外，GUCA2B還可能與胃腸道癌癥、腸易激綜合征等疾病的發(fā)生發(fā)展相關(guān)。
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功能：Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
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基因功能參考文獻：
- In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
- UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
- findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
- act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
- Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406
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亞細胞定位：Secreted.
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蛋白家族：Guanylin family
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組織特異性：Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
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數(shù)據(jù)庫鏈接：
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