GRM4 Antibody
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中文名稱：GRM4兔多克隆抗體
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貨號：CSB-PA003235
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using mGluR-4 Polyclonal Antibody -
Western Blot analysis of RAT-KIDNEY cells using mGluR-4 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Glutamate receptor metabotropic 4 antibody; GPRC1D antibody; Grm4 antibody; GRM4_HUMAN antibody; Metabotropic glutamate receptor 4 antibody; mGlu4 antibody; mGluR4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the C-terminal region of Human mGluR-4.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
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基因功能參考文獻：
- EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
- Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
- Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
- The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
- study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
- The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
- explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
- Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
- GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
- residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
- mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
- Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
- mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
- These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
- the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 3 family
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組織特異性：Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
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數據庫鏈接：
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