GRM4 Antibody

說明書

中文名稱：

GRM4兔多克隆抗體
貨號：

CSB-PA693203
規(guī)格：

￥2024
圖片：
Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR4 antibody.

Western blot analysis of extracts from 293 cells, untreated or treated with Forskolin (40nM, 30mins), using GluR4 antibody.

Western blot analysis of extracts from JK cells (Lane 2), using mGluR4 antiobdy. The lane on the left is treated with synthesized peptide.
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GRM4 Polyclonal antibody
Uniprot No.：

Q14833
基因名：

GRM4
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human GluR4.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
基因功能參考文獻：
1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
10. residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
11. mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
12. Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 3 family
組織特異性：

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
數(shù)據(jù)庫鏈接：

HGNC: 4596

OMIM: 604100

KEGG: hsa:2914

STRING: 9606.ENSP00000363296

UniGene: Hs.429018

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