GRAP2 Antibody

中文名稱：

GRAP2兔多克隆抗體
貨號：

CSB-PA009884LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA009884LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GRAP2 Polyclonal antibody
Uniprot No.：

O75791
基因名：

GRAP2
別名：

GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona), GRAP2, GADS GRB2L GRID
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GRB2-related adapter protein 2 protein (149-251aa)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GRAP2 Antibody (CSB-PA009884LA01HU)，的標記方式是Non-conjugated。對于GRAP2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009884LB01HU	GRAP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009884LC01HU	GRAP2 Antibody, FITC conjugated
Biotin	CSB-PA009884LD01HU	GRAP2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
基因功能參考文獻：
1. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
2. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity PMID: 27927989
3. GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 and PLC-gamma1 phosphorylation but exhibited substantial decrease in TCR-induced IL-2 and IFN-gamma release. PMID: 25636200
4. Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression. PMID: 25452106
5. GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates. PMID: 23399893
6. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
7. The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. PMID: 20079431
8. Upstream open reading frames regulate translation of this protein's mRNA in megakaryocytes. PMID: 12487779
9. Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase phosphorylation. PMID: 12496419
10. AML-1 plays a role in driving Mona protein expression in T and myelomonocytic cells. PMID: 12554803
11. Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase mitogenic signaling PMID: 12917638
12. Gads plays a dominant role in CD28-mediated IL-2 promoter activation. PMID: 16818765
13. The integrity of T-cell receptor signaling in vivo is sustained both by strong selection of SLP-76 for the Gads C-SH3 domain and by a capacity to buffer intrinsic crossreactivity. PMID: 17235283
14. Consistent Grap-2 expression suggests a specific role for this adaptor in human medullary thyroid carcinoma, while qualitative alterations do not appear to influence RET signaling PMID: 19027225
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亞細胞定位：

Nucleus. Cytoplasm. Endosome.
蛋白家族：

GRB2/sem-5/DRK family
數據庫鏈接：

HGNC: 4563

OMIM: 604518

KEGG: hsa:9402

STRING: 9606.ENSP00000339186

UniGene: Hs.517499

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