GRAP2 Antibody
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中文名稱：GRAP2兔多克隆抗體
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貨號：CSB-PA443192
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HuvEc cells, using GRAP2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GRAP2 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human GRAP2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
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基因功能參考文獻：
- These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
- Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity PMID: 27927989
- GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 and PLC-gamma1 phosphorylation but exhibited substantial decrease in TCR-induced IL-2 and IFN-gamma release. PMID: 25636200
- Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression. PMID: 25452106
- GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates. PMID: 23399893
- Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
- The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. PMID: 20079431
- Upstream open reading frames regulate translation of this protein's mRNA in megakaryocytes. PMID: 12487779
- Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase phosphorylation. PMID: 12496419
- AML-1 plays a role in driving Mona protein expression in T and myelomonocytic cells. PMID: 12554803
- Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase mitogenic signaling PMID: 12917638
- Gads plays a dominant role in CD28-mediated IL-2 promoter activation. PMID: 16818765
- The integrity of T-cell receptor signaling in vivo is sustained both by strong selection of SLP-76 for the Gads C-SH3 domain and by a capacity to buffer intrinsic crossreactivity. PMID: 17235283
- Consistent Grap-2 expression suggests a specific role for this adaptor in human medullary thyroid carcinoma, while qualitative alterations do not appear to influence RET signaling PMID: 19027225
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亞細胞定位：Nucleus. Cytoplasm. Endosome.
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蛋白家族：GRB2/sem-5/DRK family
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數據庫鏈接：
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