GIPC1 Antibody
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中文名稱：GIPC1兔多克隆抗體
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貨號：CSB-PA009435GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：GIPC1
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別名：GIPC1 antibody; C19orf3 antibody; GIPC antibody; RGS19IP1PDZ domain-containing protein GIPC1 antibody; GAIP C-terminus-interacting protein antibody; RGS-GAIP-interacting protein antibody; RGS19-interacting protein 1 antibody; Synectin antibody; Tax interaction protein 2 antibody; TIP-2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human GIPC1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：May be involved in G protein-linked signaling.
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基因功能參考文獻：
- Upregulated expression of GIPC1 is associated with glioma. PMID: 27481513
- Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs. PMID: 26787837
- The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
- GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells. PMID: 25469510
- GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes. PMID: 23145131
- Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer. PMID: 23128896
- a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis PMID: 22593212
- The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner. PMID: 22082268
- Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein PMID: 21432940
- GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells PMID: 21209904
- interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
- aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP PMID: 21247498
- Findings show the importance of GIPC in breast tumor progression. PMID: 21047775
- GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
- Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. PMID: 20091192
- Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
- The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. PMID: 11852236
- expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors PMID: 11956658
- GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling PMID: 12724327
- responsible for the recycling of the hormone that is internalized by the lutropin receptor and also for maintaining a relatively constant level of lutropin receptor at the cell surface during hormone internalization PMID: 14507927
- results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC PMID: 15767424
- These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I. PMID: 16225848
- GIPC can bind to itself and that the PDZ domain is involved in GIPC-GIPC interaction PMID: 16962991
- Targeting GIPC could be a promising new treatment option for pancreatic cancer. PMID: 18314626
- GIPC1 protein is overexpressed in ovarian and breast cancer PMID: 18721484
- GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer PMID: 18721486
- Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
- the C-terminal PDZ-binding motif of Glut1 plays a key role in growth factor regulation of glucose uptake by both allowing GIPC to promote Glut1 trafficking to the cell surface and protecting intracellular Glut1 from lysosomal degradation. PMID: 19016655
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亞細胞定位：Cytoplasm. Membrane; Peripheral membrane protein.
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蛋白家族：GIPC family
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組織特異性：Widely expressed. Expressed in skeletal muscle (at protein level).
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數(shù)據(jù)庫鏈接：
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