GIPC1 Antibody, HRP conjugated

說明書

中文名稱：

GIPC1兔多克隆抗體, HRP偶聯(lián)
貨號(hào)：

CSB-PA009435LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GIPC1 Polyclonal antibody
Uniprot No.：

O14908
基因名：

GIPC1
別名：

GIPC1 antibody; C19orf3 antibody; GIPC antibody; RGS19IP1PDZ domain-containing protein GIPC1 antibody; GAIP C-terminus-interacting protein antibody; RGS-GAIP-interacting protein antibody; RGS19-interacting protein 1 antibody; Synectin antibody; Tax interaction protein 2 antibody; TIP-2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human PDZ domain-containing protein GIPC1 protein (7-74AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May be involved in G protein-linked signaling.
基因功能參考文獻(xiàn)：
1. Upregulated expression of GIPC1 is associated with glioma. PMID: 27481513
2. Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs. PMID: 26787837
3. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
4. GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells. PMID: 25469510
5. GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes. PMID: 23145131
6. Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer. PMID: 23128896
7. a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis PMID: 22593212
8. The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner. PMID: 22082268
9. Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein PMID: 21432940
10. GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells PMID: 21209904
11. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
12. aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP PMID: 21247498
13. Findings show the importance of GIPC in breast tumor progression. PMID: 21047775
14. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
15. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. PMID: 20091192
16. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
17. The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. PMID: 11852236
18. expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors PMID: 11956658
19. GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling PMID: 12724327
20. responsible for the recycling of the hormone that is internalized by the lutropin receptor and also for maintaining a relatively constant level of lutropin receptor at the cell surface during hormone internalization PMID: 14507927
21. results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC PMID: 15767424
22. These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I. PMID: 16225848
23. GIPC can bind to itself and that the PDZ domain is involved in GIPC-GIPC interaction PMID: 16962991
24. Targeting GIPC could be a promising new treatment option for pancreatic cancer. PMID: 18314626
25. GIPC1 protein is overexpressed in ovarian and breast cancer PMID: 18721484
26. GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer PMID: 18721486
27. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
28. the C-terminal PDZ-binding motif of Glut1 plays a key role in growth factor regulation of glucose uptake by both allowing GIPC to promote Glut1 trafficking to the cell surface and protecting intracellular Glut1 from lysosomal degradation. PMID: 19016655
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亞細(xì)胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
蛋白家族：

GIPC family
組織特異性：

Widely expressed. Expressed in skeletal muscle (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 1226

OMIM: 605072

KEGG: hsa:10755

STRING: 9606.ENSP00000340698

UniGene: Hs.655012

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