GCNT2 Antibody

說明書

中文名稱：

GCNT2兔多克隆抗體
貨號：

CSB-PA844048ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: GCNT2 antibody at 3.99µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Mouse placenta tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 47 kDa
Observed band size: 46 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA844048ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA844048ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GCNT2 Polyclonal antibody
Uniprot No.：

Q8N0V5
基因名：

GCNT2
別名：

GCNT2 antibody; GCNT5 antibody; II antibody; NACGT1 antibody; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase antibody; N-acetylglucosaminyltransferase antibody; EC 2.4.1.150 antibody; I-branching enzyme antibody; IGNT antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase protein (203-402AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.; Determines the expression of the blood group I antigen in erythrocytes.
基因功能參考文獻：
1. miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT PMID: 28542779
2. This study reports a novel insertion/deletion mutation at the GCNT2 locus that is responsible for congenital cataracts in a large consanguineous family. PMID: 27936067
3. GCNT2 expression is closely associated with invasive potential of prostate cancer. PMID: 26678556
4. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of colorectal cancer in the tumor and normal tissues. PMID: 25750292
5. An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group PMID: 21761136
6. Results show involvement of GCNT2 in EMT and TGF-beta signaling, and further glycosylation modification of E-cadherin by GCNT2, are the underlying integrative mechanisms for breast cancer metastasis. PMID: 21750175
7. In the family with the "ii" blood group a novel GCNT2 mutation was found in the cataract patients. PMID: 21541272
8. The I carbohydrate antigen interacts simultaneously with the entire hydrophobic patch in framework region 1 and with the outside surface of Ig heavy chain complementarity-determining region 3, leaving most of the site available for binding other antigens. PMID: 12244172
9. A nonsense mutation in the GCNT2 gene isoforms is associated with autosomal recessive congenital cataract in four distantly related Arab families from Israel. PMID: 15161861
10. role of C/EBPalpha in the induction of the IGnTC gene as well as in I antigen expression PMID: 17855628
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相關疾?。?/div>
Cataract 13, with adult i phenotype (CTRCT13)
亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 14 family
組織特異性：

[Isoform B]: Expressed in lens epithelium cells.; [Isoform C]: Expressed in reticulocytes.
數據庫鏈接：

HGNC: 4204

OMIM: 110800

KEGG: hsa:2651

STRING: 9606.ENSP00000265012

UniGene: Hs.519884

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