FRK Antibody
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中文名稱：FRK兔多克隆抗體
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貨號：CSB-PA215571
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規格：￥1100
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圖片：
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The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA215571(FRK Antibody) at dilution 1/40. (Original magnification: ×200) -
The image is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA215571(FRK Antibody) at dilution 1/40. (Original magnification: ×200) -
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA215571(FRK Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：FRK
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別名：Beta cell Src homology tyrosine kinase antibody; BSK antibody; BSK/IYK antibody; C85044 antibody; Frk antibody; Frk fyn related kinase antibody; FRK_HUMAN antibody; FYN related kinase antibody; FYN-related kinase antibody; GASK antibody; Gastrointestinal associated kinase antibody; Gastrointestinal associated tyrosine kinase antibody; GTK antibody; GTK; mouse; homolog of antibody; Intestine tyrosine kinase antibody; Nuclear tyrosine protein kinase RAK antibody; Protein-tyrosine kinase 5 antibody; PTK5 antibody; PTK5 protein tyrosine kinase 5 antibody; RAK antibody; Tyrosine protein kinase FRK antibody; Tyrosine-protein kinase FRK antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human FRK
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
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基因功能參考文獻：
- our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. PMID: 28077797
- Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. PMID: 27665472
- antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. PMID: 25783528
- our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. PMID: 24792491
- FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. PMID: 24969324
- exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors PMID: 24735922
- Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. PMID: 23318459
- The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. PMID: 23267173
- these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion PMID: 22790444
- Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
- Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. PMID: 21074287
- Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase PMID: 12569567
- The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
- Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. PMID: 15082191
- Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. PMID: 19345329
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亞細胞定位：Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
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蛋白家族：Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
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組織特異性：Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
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數據庫鏈接：
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