FRK Antibody

說明書

中文名稱：

FRK兔多克隆抗體
貨號：

CSB-PA237384
規格：

￥2024
圖片：
Western blot analysis of extracts from Jurkat cells, using FRK antibody.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using FRK antibody.

Immunofluorescence analysis of HUVEC cells, using FRK antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FRK Polyclonal antibody
Uniprot No.：

P42685
基因名：

FRK
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human FRK.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
基因功能參考文獻：
1. our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. PMID: 28077797
2. Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. PMID: 27665472
3. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. PMID: 25783528
4. our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. PMID: 24792491
5. FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. PMID: 24969324
6. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors PMID: 24735922
7. Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. PMID: 23318459
8. The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. PMID: 23267173
9. these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion PMID: 22790444
10. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
11. Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. PMID: 21074287
12. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase PMID: 12569567
13. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
14. Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. PMID: 15082191
15. Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. PMID: 19345329
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亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
組織特異性：

Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
數據庫鏈接：

HGNC: 3955

OMIM: 606573

KEGG: hsa:2444

STRING: 9606.ENSP00000357615

UniGene: Hs.89426

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