EPB41L2 Antibody

說明書

中文名稱：

EPB41L2兔多克隆抗體
貨號：

CSB-PA000768
規(guī)格：

￥1090
圖片：
Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody

Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody
其他：

產(chǎn)品詳情

Uniprot No.：

O43491
基因名：

EPB41L2
別名：

4.1 G antibody; 4.1G antibody; AW555191 antibody; Band 4.1 like protein 2 antibody; Band 4.1-like protein 2 antibody; D10Ertd398e antibody; DKFZp781D1972 antibody; DKFZp781H1755 antibody; E41L2_HUMAN antibody; Epb41l2 antibody; Erythrocyte membrane protein band 4.1 like 2 antibody; Erythrocyte membrane protein band 4.1 like protein 2 antibody; Generally expressed protein 4.1 antibody; NBL2 antibody; OTTHUMP00000017197 antibody; OTTHUMP00000040262 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human 4.1G.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
基因功能參考文獻：
1. Ca(2+)/CaM binding to GHP, and more specifically to pepG, has profound effects on other functional domains of 4.1G PMID: 23354586
2. 4.1G protein depresses PTH-related protein receptor-mediated Gs signaling pathway by suppression of adenylyl cyclase-mediated cAMP production. PMID: 23201780
3. A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling. PMID: 22003208
4. PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex PMID: 15138281
5. An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. PMID: 18023480
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane.
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 3379

OMIM: 603237

KEGG: hsa:2037

STRING: 9606.ENSP00000338481

UniGene: Hs.486470

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