EPB41L2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

O43491
基因名：

EPB41L2
別名：

4.1 G antibody; 4.1G antibody; AW555191 antibody; Band 4.1 like protein 2 antibody; Band 4.1-like protein 2 antibody; D10Ertd398e antibody; DKFZp781D1972 antibody; DKFZp781H1755 antibody; E41L2_HUMAN antibody; Epb41l2 antibody; Erythrocyte membrane protein band 4.1 like 2 antibody; Erythrocyte membrane protein band 4.1 like protein 2 antibody; Generally expressed protein 4.1 antibody; NBL2 antibody; OTTHUMP00000017197 antibody; OTTHUMP00000040262 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human EPB41L2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
基因功能參考文獻(xiàn)：
1. Ca(2+)/CaM binding to GHP, and more specifically to pepG, has profound effects on other functional domains of 4.1G PMID: 23354586
2. 4.1G protein depresses PTH-related protein receptor-mediated Gs signaling pathway by suppression of adenylyl cyclase-mediated cAMP production. PMID: 23201780
3. A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling. PMID: 22003208
4. PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex PMID: 15138281
5. An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. PMID: 18023480
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane.
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 3379

OMIM: 603237

KEGG: hsa:2037

STRING: 9606.ENSP00000338481

UniGene: Hs.486470

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