EIF3K Antibody
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中文名稱：EIF3K兔多克隆抗體
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貨號：CSB-PA693741
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HeLa cells, using EIF3K antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) EIF3K Polyclonal antibody
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Uniprot No.：
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基因名：EIF3K
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human EIF3K.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
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基因功能參考文獻：
- eIF3K subunit interacts directly with the PML protein. PMID: 24036361
- identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24] PMID: 12006665
- eIF3k has three putative protein-binding surfaces and has potential RNA binding activity PMID: 15180986
- cyclin D3 specifically interacted with eIF3k through its C-terminal domain; eIF3k distributed both in nucleus and cytoplasm and colocalized with cyclin D3 PMID: 15327989
- eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation factor 3 (eIF3) complexes, also localizes to keratin intermediate filaments and physically associates with K18 in epithelial cells. PMID: 18577580
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：EIF-3 subunit K family
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組織特異性：Ubiquitous, with the highest levels of expression in brain, testis and kidney.
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數據庫鏈接：
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