EGR3 Antibody

說(shuō)明書

中文名稱：

EGR3兔多克隆抗體
貨號(hào)：

CSB-PA007981
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q06889
基因名：

EGR3
別名：

EGR3 antibody; PILOTEarly growth response protein 3 antibody; EGR-3 antibody; Zinc finger protein pilot antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the C-terminal region of Human Egr-3.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Probable transcription factor involved in muscle spindle development.
基因功能參考文獻(xiàn)：
1. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
2. miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC PMID: 28070994
3. EGR3 contributes to cell growth inhibition via upregulation of FasL in Hepatocellular carcinoma. PMID: 28098878
4. These findings support previously reported associations between EGR3 and schizophrenia. PMID: 26474411
5. EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer. PMID: 25633035
6. Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China PMID: 24886494
7. Genetic variation in EGR3 may affect prefrontal function through neurodevelopment PMID: 23962955
8. These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses. PMID: 23906810
9. Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells. PMID: 23460371
10. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. PMID: 23935197
11. Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity PMID: 23904169
12. Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse. PMID: 23342084
13. EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1. PMID: 22370066
14. Study supports the association of EGR3 with schizophrenia in Han Chinese sample. PMID: 22276163
15. EGR3 gene may play an important role in schizophrenia susceptibility PMID: 22425949
16. EGR3 bound to the TREM-1 promoter. PMID: 21421043
17. This study demoistrated that ERG3 are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
18. SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia PMID: 20687139
19. Egr-3 is a critical determinant of VEGF signaling in activated endothelial cells PMID: 19965691
20. Vascularendothelial growth factor induces expression of NR4A nuclear receptors and Egr3 via KDR and KDR-mediated signaling mechanisms. PMID: 14525795
21. data suggest that Egr3 is a target for the estrogen receptor alpha PMID: 15171706
22. These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene. PMID: 17360599
23. findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease PMID: 18059339
24. Enforced expression of Egr3 transgene, from the CD2 antigen promoter, facilitates development of RAG2-deficient double-negative (DN) stage 3 thymocytes to the DN4 stage and subsequently to the double-positive stage of development. PMID: 19124717
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

EGR C2H2-type zinc-finger protein family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 3240

OMIM: 602419

KEGG: hsa:1960

STRING: 9606.ENSP00000318057

UniGene: Hs.534313

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