EEF1E1 Antibody

中文名稱：

EEF1E1兔多克隆抗體
貨號：

CSB-PA007432LA01HU
規格：

￥440
圖片：
Western blot
All lanes: EEF1E1 antibody at 2µg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 20, 16 kDa
Observed band size: 20 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007432LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA007432LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) EEF1E1 Polyclonal antibody
Uniprot No.：

O43324
基因名：

EEF1E1
別名：

AIMP 3 antibody; AIMP3 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 3 antibody; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3 antibody; ARS interacting multifunctional protein 3 antibody; EEF1E1 antibody; Elongation factor p18 antibody; Eukaryotic translation elongation factor 1 epsilon 1 antibody; Eukaryotic translation elongation factor 1 epsilon-1 antibody; Homolog of rat elongation factor p18 antibody; MCA3_HUMAN antibody; Multisynthase complex auxiliary component p18 antibody; Multisynthetase complex auxiliary component p18 antibody; p18 antibody; p18 component of aminoacyl tRNA synthetase complex antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Eukaryotic translation elongation factor 1 epsilon-1 protein (2-174AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，EEF1E1 Antibody (CSB-PA007432LA01HU)，的標記方式是Non-conjugated。對于EEF1E1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA007432LB01HU	EEF1E1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007432LC01HU	EEF1E1 Antibody, FITC conjugated
Biotin	CSB-PA007432LD01HU	EEF1E1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Positive modulator of ATM response to DNA damage.
基因功能參考文獻：
1. LmnA binds AIMP3 via its extreme C-terminus. Together these findings provide a structural insight for understanding the interaction between AIMP3 and LmnA in AIMP3 degradation. PMID: 28797100
2. AIMP3 was shown to be involved in the cellular aging of human mesenchymal stem cells. PMID: 25465621
3. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
4. AIMP3 stabilizes and protects methionyl-tRNA synthetase and eIF2gamma through the binding interactions. PMID: 23306449
5. AIMP3 is a critical mediator of Met-tRNA(i)(Met) transfer from methionyl-tRNA synthetase to eIF2 complex for the accurate and efficient translation initiation PMID: 22867704
6. Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
7. Decreased expression of AIMP3 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC. PMID: 21789020
8. p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation. PMID: 15680327
9. analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with PMID: 18343821
10. No EEF1E1 mutations were detected in human cancer specimens. PMID: 19024604
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亞細胞定位：

Cytoplasm. Cytoplasm, cytosol. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.
組織特異性：

Down-regulated in various cancer tissues.
數據庫鏈接：

HGNC: 3212

OMIM: 609206

KEGG: hsa:9521

STRING: 9606.ENSP00000369038

UniGene: Hs.602353

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