ECD Antibody
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中文名稱：ECD兔多克隆抗體
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貨號(hào)：CSB-PA007370GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ECD
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別名：ecd antibody; ECD_HUMAN antibody; Ecdysoneless homolog antibody; hSGT1 antibody; Human suppressor of GCR two antibody; Protein ecdysoneless homolog antibody; SGT 1 antibody; SGT1 protein antibody; Suppressor of GCR2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Human ECD
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
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基因功能參考文獻(xiàn)：
- The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. PMID: 26711270
- Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice. PMID: 25616580
- Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. PMID: 22977192
- Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. PMID: 22270930
- Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator. PMID: 19919181
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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蛋白家族：ECD family
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組織特異性：Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.
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數(shù)據(jù)庫鏈接：
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