ECD Antibody
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中文名稱：ECD兔多克隆抗體
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貨號：CSB-PA007370LA01HU
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規格：￥440
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圖片：
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Western blot
All lanes: ECD antibody at 6µg/ml
Lane 1: Hela whole cell lysate
Lane 2: U251 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 73, 68, 77 kDa
Observed band size: 73 kDa
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ECD Polyclonal antibody
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Uniprot No.：
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基因名：ECD
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別名：ecd antibody; ECD_HUMAN antibody; Ecdysoneless homolog antibody; hSGT1 antibody; Human suppressor of GCR two antibody; Protein ecdysoneless homolog antibody; SGT 1 antibody; SGT1 protein antibody; Suppressor of GCR2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Protein ecdysoneless homolog protein (1-300AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，ECD Antibody (CSB-PA007370LA01HU)，的標記方式是Non-conjugated。對于ECD Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
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基因功能參考文獻：
- The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. PMID: 26711270
- Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice. PMID: 25616580
- Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. PMID: 22977192
- Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. PMID: 22270930
- Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator. PMID: 19919181
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：ECD family
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組織特異性：Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.
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數據庫鏈接：
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