DNAJA3 Antibody, HRP conjugated
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中文名稱：DNAJA3兔多克隆抗體, HRP偶聯(lián)
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貨號(hào)：CSB-PA836207LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) DNAJA3 Polyclonal antibody
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Uniprot No.：
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基因名：DNAJA3
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別名：DNAJA3 antibody; HCA57 antibody; TID1DnaJ homolog subfamily A member 3 antibody; mitochondrial antibody; DnaJ protein Tid-1 antibody; hTid-1 antibody; Hepatocellular carcinoma-associated antigen 57 antibody; Tumorous imaginal discs protein Tid56 homolog antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human DnaJ homolog subfamily A member 3, mitochondrial protein (86-184AA )
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
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基因功能參考文獻(xiàn)：
- Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function. PMID: 25904328
- The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB Signaling. PMID: 26245905
- TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition PMID: 24492964
- Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation. PMID: 23698466
- Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability. PMID: 22595283
- loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin PMID: 22692211
- Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival. PMID: 21710689
- findings denote hTid-1(S) as an essential regulatory component of MetR signaling PMID: 21242965
- hTid1 negatively regulates the expression and transcriptional activity of STAT5b and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b. PMID: 21106534
- htid is a tissue independent and evolutionarily conserved suppressor of ErbB-2. PMID: 20565727
- amino-terminal segment of APC promotes cell sensitivity to apoptosis modulated through its binding to 40- and 43-kilodalton hTID-1 isoforms. PMID: 19900451
- role as a repressor of Ikappa B kinase beta subunit PMID: 11927590
- Tid-1S in Th2 cells following activation has a role in induction of apoptosis resistance during the activation of Th2 cells PMID: 12879007
- an important cell death regulator and could exert tumor suppressor activity PMID: 15156195
- findings suggest that the status of hTid-1 in gliomas may contribute to their susceptibility to cell death triggers PMID: 15589840
- hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB PMID: 15601829
- the carboxyl-terminal end of TID1 (residues 224-429) bound to Trk at the activation loop (Tyr(P)(683)-Tyr(684)(P)(684) PMID: 15753086
- Tid1 is critical for the transition of double-negative to double-positive cells in early T cell development through modulation of antiapoptotic bcl-2 expression. PMID: 15879105
- Tid1 negatively regulates the motility and metastasis of breast cancer cells, most likely through attenuation of nuclear factor kappaB activity on the promoter of the IL8 gene. PMID: 16204048
- hTid1 may act as a chaperone to facilitate the folding, processing and maturation of Epstein-Barr virus-encoded BARF1 protein. PMID: 16518412
- The association of Tid1 with chaperones and/or protein substrates in the cytosol provides a mechanism for the alternate fates and functions of Tid1 in mitochondrial and nonmitochondrial pathways. PMID: 16531398
- The association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor is shown. PMID: 17588722
- The expression of the genes htid-1 and APC was altered in colorectal tumors. PMID: 18097612
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亞細(xì)胞定位：Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein.
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組織特異性：Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
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