DHODH Antibody, HRP conjugated
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中文名稱：DHODH兔多克隆抗體, HRP偶聯
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貨號：CSB-PA006852LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DHODH Polyclonal antibody
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Uniprot No.：
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基因名：DHODH
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別名：DHOdehase antibody; Dhodh antibody; Dihydroorotate dehydrogenase (quinone) antibody; Dihydroorotate dehydrogenase antibody; Dihydroorotate dehydrogenase mitochondrial antibody; Dihydroorotate oxidase antibody; Human complement of yeast URA1 antibody; mitochondrial antibody; POADS antibody; PYRD_HUMAN antibody; URA1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial protein (241-395AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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基因功能參考文獻：
- This case with grossly raised plasma DHO represents the first biochemical confirmation of functional DHODH deficiency. DHO was also easily detectable in dried plasma and blood spots. PMID: 27370710
- This is the first study to report on conformational changes of the HsDHODH N-terminal microdomain through a combination of CD and DEER spectroscopic techniques PMID: 26086954
- Considering that pyrimidine deficiency alone does not induce craniofacial dysmorphism, the DHODH mutations may contribute to the Miller syndrome in part through somehow altered mitochondrial function. PMID: 23216091
- Carriage of a six-marker DHODH haplotype was associated with a reduced treatment response (p = 0.008). PMID: 22966891
- The G202A and R346W mutation causes deficient protein stability, and the R135C mutation impairs the substrate-induced enzymatic activity, suggesting that impairment of DHODH activity is linked to the Miller syndrome phenotype. PMID: 22967083
- biallelic DHODH mutations in four unrelated families with typical clinical features of Miller syndrome. PMID: 22692683
- DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in xenograft studies PMID: 21430780
- DHODH recessively causes Miller syndrome. PMID: 20220176
- required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis of cancer epithelial cells PMID: 20399851
- Data confirmed the presence of DHODH mutations in families with Miller syndrome. PMID: 19915526
- biophysical analysis of hydrogen bonding pathways in human dihydroorotate dehydrogenase PMID: 17004840
- Data provide new insights into the dynamic features of the DHODH reaction and suggest new approaches to the design of inhibitors against DHODH. PMID: 18672895
- DHODH polymorphism may be associated with incireased remiaaion in leflunomide treatment in rheumatoid arthritis patients. PMID: 19207032
- we report a new association of DHODH A40C polymorphism with leflunomide toxicity in patients with Rheumatoid Arthritis. PMID: 19605743
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相關疾病：Postaxial acrofacial dysostosis (POADS)
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亞細胞定位：Mitochondrion inner membrane; Single-pass membrane protein.
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蛋白家族：Dihydroorotate dehydrogenase family, Type 2 subfamily
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數據庫鏈接：
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