DEF6 Antibody

中文名稱：

DEF6兔多克隆抗體
貨號：

CSB-PA884467LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue
All lanes: DEF6 antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 74 kDa
Observed band size: 74 kDa

Immunofluorescent analysis of U251 cells using CSB-PA884467LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DEF6 Polyclonal antibody
Uniprot No.：

Q9H4E7
基因名：

DEF6
別名：

DEF-6 antibody; Def6 antibody; DEFI6_HUMAN antibody; Differentially expressed in FDCP 6 homolog antibody; Differentially expressed in FDCP 6 homologue mouse antibody; IBP antibody; IRF4-binding protein antibody; Swap70 like adapter of T cells antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Differentially expressed in FDCP 6 homolog protein (20-114AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DEF6 Antibody (CSB-PA884467LA01HU)，的標記方式是Non-conjugated。對于DEF6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA884467LB01HU	DEF6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA884467LC01HU	DEF6 Antibody, FITC conjugated
Biotin	CSB-PA884467LD01HU	DEF6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
基因功能參考文獻：
1. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival. PMID: 27488395
3. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases PMID: 23088770
4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. PMID: 22829599
5. Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system. PMID: 12651066
6. IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement PMID: 12923183
7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function PMID: 17121847
8. level of expression correlates with the degree of malignancy in breast carcinoma tissues PMID: 19393345
9. Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma. PMID: 19679060
10. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. PMID: 15023524
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亞細胞定位：

Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
組織特異性：

Broadly expressed in the immune system and can be detected in T and B-cells.
數據庫鏈接：

HGNC: 2760

OMIM: 610094

KEGG: hsa:50619

STRING: 9606.ENSP00000319831

UniGene: Hs.15476

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