DEF6 Antibody
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中文名稱：DEF6兔多克隆抗體
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貨號：CSB-PA006650GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：DEF6
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別名：DEF-6 antibody; Def6 antibody; DEFI6_HUMAN antibody; Differentially expressed in FDCP 6 homolog antibody; Differentially expressed in FDCP 6 homologue mouse antibody; IBP antibody; IRF4-binding protein antibody; Swap70 like adapter of T cells antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human DEF6
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
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基因功能參考文獻：
- this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
- DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival. PMID: 27488395
- IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases PMID: 23088770
- DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. PMID: 22829599
- Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system. PMID: 12651066
- IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement PMID: 12923183
- DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function PMID: 17121847
- level of expression correlates with the degree of malignancy in breast carcinoma tissues PMID: 19393345
- Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma. PMID: 19679060
- DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. PMID: 15023524
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亞細胞定位：Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
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組織特異性：Broadly expressed in the immune system and can be detected in T and B-cells.
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數據庫鏈接：
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