Cleaved-CTSZ (L62) Antibody

說明書

中文名稱：

Cleaved-CTSZ (L62)兔多克隆抗體
貨號：

CSB-PA000038
規格：

￥1090
圖片：
Western Blot analysis of COS7 cells using Cleaved-Cathepsin Z (L62) Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UBR2
基因名：

CTSZ
別名：

Carboxypeptidase LB antibody; Cathepsin B2 antibody; Cathepsin IV antibody; Cathepsin P antibody; Cathepsin X antibody; Cathepsin X precursor antibody; Cathepsin Y antibody; Cathepsin Z antibody; Cathepsin Z precursor antibody; Cathepsin Z1 antibody; CathepsinP antibody; CathepsinX antibody; CathepsinZ antibody; CATZ_HUMAN antibody; CTSX antibody; CTSZ antibody; Cysteine type carboxypeptidase antibody; FLJ17088 antibody; Lysosomal carboxypeptidase B antibody; Preprocathepsin P antibody; PreprocathepsinP antibody
宿主：

Rabbit
反應種屬：

Human,Monkey
免疫原：

Synthesized peptide derived from the Internal region of Human Cathepsin Z.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
基因功能參考文獻：
1. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis PMID: 25433997
2. Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. PMID: 25442015
3. The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. PMID: 24725597
4. Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. PMID: 23827504
5. We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form PMID: 21454358
6. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
7. cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. PMID: 21616554
8. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. PMID: 21368909
9. associated with tuberculosis in a Ugandan household contact study PMID: 21354459
10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
11. These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity. PMID: 15680921
12. the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] PMID: 17065156
13. unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations PMID: 18420963
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亞細胞定位：

Lysosome.
蛋白家族：

Peptidase C1 family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 2547

OMIM: 603169

KEGG: hsa:1522

STRING: 9606.ENSP00000217131

UniGene: Hs.252549

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