CSTF2 Antibody

說明書

中文名稱：

CSTF2兔多克隆抗體
貨號：

CSB-PA335813ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: CSTF2 antibody at 6μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 61, 60 kDa
Observed band size: 61 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA335813ESR1HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CSTF2 Polyclonal antibody
Uniprot No.：

P33240
基因名：

CSTF2
別名：

betaCstF 64 variant 2 antibody; CF-1 64 kDa subunit antibody; CF1 64 kDa subunit antibody; Cleavage stimulation factor 2 antibody; Cleavage stimulation factor 64 kDa subunit antibody; Cleavage stimulation factor subunit 2 antibody; Cleavage stimulation factor; 3' pre RNA; subunit 2; 64kDa antibody; CSTF 2 antibody; CstF 64 antibody; CSTF 64 kDa subunit antibody; CstF-64 antibody; CSTF2 antibody; CSTF2_HUMAN antibody; MGC188397 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cleavage stimulation factor subunit 2 protein (1-180AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.
基因功能參考文獻：
1. hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. PMID: 28180311
2. CstF-64 is dispensable for the expression/3'-end processing of Star-PAP target mRNAs.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
3. CstF64, an essential polyadenylation factor, is a master regulator of 3'-UTR shortening across multiple tumour types. PMID: 25409906
4. CstF64 is central to the function of a heat-labile factor, composed of cleavage/polyadenylation specificity factor, symplekin, and cleavage stimulation factor 64 and appears to be at least partly responsible for its cell cycle regulation. PMID: 25266659
5. CstF64 and CstF64tau modulate one another's expression and play overlapping as well as distinct roles in regulating global alternative polyadenylation profiles. PMID: 24149845
6. CstF64 binds to thousands of dormant intronic PASs that are suppressed, at least in part, by U1 small nuclear ribonucleoproteins PMID: 23112178
7. CSTF2 is likely to play an important role in lung carcinogenesis and be a prognostic biomarker in the clinic. PMID: 21813631
8. nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function PMID: 21119002
9. The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization. PMID: 19887456
10. dynamics of the CstF-64 RNA-binding domain, both free and bound to two GU-rich RNA sequences that represent polyadenylation regulatory elements, by NMR Spectroscopy PMID: 15769465
11. The inactivity of the RSV poly(A) site was at least in part due to poor CstF binding since tethering CstF to the RSV substrate activated polyadenylation. PMID: 18272196
12. CstF64 (cstf2) and not other CstF subunits induced by lipopolysaccharide (LPS) in murine macrophages and changes polyA site use PMID: 16207706
13. Describes the induction of CSTF2 in the growth phase of cells. PMID: 9736695
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亞細胞定位：

Nucleus. Note=Localized with DDX1 in cleavage bodies.
數據庫鏈接：

HGNC: 2484

OMIM: 300907

KEGG: hsa:1478

STRING: 9606.ENSP00000362063

UniGene: Hs.132370

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