CSTF2 Antibody
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中文名稱：CSTF2兔多克隆抗體
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貨號：CSB-PA092943
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規格：￥2024
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圖片：
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Western blot analysis of extracts from 293 cells. HepG2 cells and Jurkat cells, using CSTF2 antibody. -
Immunofluorescence analysis of HeLa cells, using CSTF2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CSTF2 Polyclonal antibody
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Uniprot No.：
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基因名：CSTF2
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from N-terminal of Human CSTF2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.
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基因功能參考文獻：
- hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. PMID: 28180311
- CstF-64 is dispensable for the expression/3'-end processing of Star-PAP target mRNAs.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
- CstF64, an essential polyadenylation factor, is a master regulator of 3'-UTR shortening across multiple tumour types. PMID: 25409906
- CstF64 is central to the function of a heat-labile factor, composed of cleavage/polyadenylation specificity factor, symplekin, and cleavage stimulation factor 64 and appears to be at least partly responsible for its cell cycle regulation. PMID: 25266659
- CstF64 and CstF64tau modulate one another's expression and play overlapping as well as distinct roles in regulating global alternative polyadenylation profiles. PMID: 24149845
- CstF64 binds to thousands of dormant intronic PASs that are suppressed, at least in part, by U1 small nuclear ribonucleoproteins PMID: 23112178
- CSTF2 is likely to play an important role in lung carcinogenesis and be a prognostic biomarker in the clinic. PMID: 21813631
- nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function PMID: 21119002
- The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization. PMID: 19887456
- dynamics of the CstF-64 RNA-binding domain, both free and bound to two GU-rich RNA sequences that represent polyadenylation regulatory elements, by NMR Spectroscopy PMID: 15769465
- The inactivity of the RSV poly(A) site was at least in part due to poor CstF binding since tethering CstF to the RSV substrate activated polyadenylation. PMID: 18272196
- CstF64 (cstf2) and not other CstF subunits induced by lipopolysaccharide (LPS) in murine macrophages and changes polyA site use PMID: 16207706
- Describes the induction of CSTF2 in the growth phase of cells. PMID: 9736695
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亞細胞定位：Nucleus. Note=Localized with DDX1 in cleavage bodies.
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數據庫鏈接：
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