COTL1 Antibody

中文名稱：

COTL1兔多克隆抗體
貨號：

CSB-PA622751HA01HU
規格：

￥440
圖片：
Western blot
All lanes: COTL1 antibody at 8µg/ml
Lane 1: Mouse brain tissue
Lane 2: Hela whole cell lysate
Lane 3: Mouse kidney tissue
Lane 4: HepG2 whole cell lysate
Lane 5: Mouse thymus tissue
Lane 6: U87 whole cell lysate
Lane 7: HL60 whole cell lysate
Lane 8: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa

Immunohistochemistry of paraffin-embedded human lymphoid tissue using CSB-PA622751HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA622751HA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) COTL1 Polyclonal antibody
Uniprot No.：

Q14019
基因名：

COTL1
別名：

CLP antibody; Coactosin like 1 antibody; Coactosin-like protein antibody; COTL1 antibody; COTL1_HUMAN antibody; FLJ43657 antibody; MGC19733 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Coactosin-like protein (2-142AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，COTL1 Antibody (CSB-PA622751HA01HU)，的標記方式是Non-conjugated。對于COTL1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA622751HB01HU	COTL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA622751HC01HU	COTL1 Antibody, FITC conjugated
Biotin	CSB-PA622751HD01HU	COTL1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
基因功能參考文獻：
1. Study uncovers a novel tumor-suppressor role for CLP/Cotl1 and identify the downstream effectors interleukin 24 (IL-24)/PERP and IL-24/MAPK/ERK/TGF-beta. PMID: 28925397
2. our combined results elucidated genetic and epigenetic silencing of miR-506-3p enhances COTL1 oncogene expression to foster NSCLC progression. PMID: 27893417
3. The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied. PMID: 25034252
4. COTL1 regulates lamellipodia dynamics in part by protecting F-actin from cofilin-mediated disassembly. PMID: 24454796
5. PAI-RBP1 and C1orf142 expression levels are higher in 95D (high metastatic potential) than in 95C (low metastatic potential) non-small lung cancer cells, whereas COTL1 expression level is lower in 95D when compared to 95C cells. PMID: 22373659
6. Up-regulated COTL-1 expression in small cell lung cancer was validated by Western blot analysis, immunohistochemistry, and qRT-qPCR. PMID: 21047053
7. Results of the present study support a role for CLP as a chaperoning scaffold factor, influencing both the stability and the activity of 5-LO. PMID: 19807693
8. CLP 57-65 peptide elicits immediate-type hypersensitivity. Identical peptides are recognized by cellular and humoral immune systems to a tumor-associated antigen. CLP 15-24 and 104-113 might be used for peptide-based immunotherapy of HLA-A2(+) cancers. PMID: 11870627
9. NMR resonance assignments and the secondary structures of human Coactosin like protein (hCLP) D123N PMID: 15213466
10. coactosin-like protein (CLP) is an actin-binding protein as well as a 5-lipoxygenase binding partner PMID: 15333945
11. structural analysis shows that CLP forms a polymer along the crystallographic b axis with the exact same repeat distance as F-actin; a model for the CLP polymer and F-actin binding has therefore been proposed. PMID: 15459340
12. preliminary crystallographic studies of human coactosin-like protein (CLP) PMID: 15583396
13. Coactosin-like protein (CLP) up-regulates Ca(2+)-induced 5-lipoxygenase (5LO) activity, and increases the amount of Leukotriene A(4) formed by 5LO. PMID: 16924104
14. extended region of beta4-beta5 of hCLP (residue 66-75) was found very flexible and very important for F-actin binding. The C-terminal residues of human coactosin-like protein were not involved in F-actin binding PMID: 17070122
15. We found that coactosin-like1 (COTL1) were highly expressed in rheumatoid arthritis patients compared with healthy controls PMID: 19307756
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
蛋白家族：

Actin-binding proteins ADF family, Coactosin subfamily
組織特異性：

Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
數據庫鏈接：

HGNC: 18304

OMIM: 606748

KEGG: hsa:23406

STRING: 9606.ENSP00000262428

UniGene: Hs.289092

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