CNOT4 Antibody
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中文名稱(chēng)：CNOT4兔多克隆抗體
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貨號(hào)：CSB-PA020140
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：CNOT4
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別名：CCR4 NOT transcription complex subunit 4 antibody; CCR4-associated factor 4 antibody; CCR4-NOT transcription complex subunit 4 antibody; CLONE243 antibody; CNOT 4 antibody; Cnot4 antibody; CNOT4_HUMAN antibody; E3 ubiquitin-protein ligase CNOT4 antibody; NOT 4 antibody; NOT4 (negative regulator of transcription 4 yeast) homolog antibody; NOT4 antibody; NOT4H antibody; Potential transcriptional repressor NOT4Hp antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human CNOT4.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
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基因功能參考文獻(xiàn)：
- These results indicate that CNOT4 is a ubiquitin ligase of influenza A virus nucleoprotein, and ubiquitination of the nucleoprotein plays a positive role in viral RNA replication. PMID: 28536288
- CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. PMID: 25933433
- Single nucleotide polymorphism in CNOT4 gene is associated with osteosarcoma susceptibility. PMID: 25663449
- Data show that Not4/CNOT4 is a novel positive regulator of the JAK/STAT pathway in Drosophila and in humans. PMID: 22159038
- Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective PMID: 15001359
- Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT4 binds CNOT1 in yeast two-hybrid assays. PMID: 19558367
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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數(shù)據(jù)庫(kù)鏈接：
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