CLEC4A Antibody
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中文名稱：CLEC4A兔多克隆抗體
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貨號：CSB-PA412681
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規格：￥1090
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圖片：
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Western Blot analysis of HEPG2 cells using CLECSF6 Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000 -
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody; C type lectin antibody; C type lectin DDB27 antibody; C type lectin superfamily 6 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 6 antibody; C-type lectin superfamily member 6 antibody; C-type lectin DDB27 antibody; C-type lectin domain family 4 member A antibody; C-type lectin domain family 4; member A antibody; C-type lectin domain family 4; member a2 antibody; C-type lectin superfamily member 6 antibody; CLC4A_HUMAN antibody; Clec4a antibody; Clec4a2 antibody; CLECSF6 antibody; DCIR antibody; Dcir1 antibody; DDB27 antibody; Dendritic cell immunoreceptor antibody; HDCGC13P antibody; Lectin like immunoreceptor antibody; Lectin; C-type; superfamily member 6 antibody; Lectin-like immunoreceptor antibody; LLIR antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from CLECSF6 at AA range: 161-210
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB,ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-2000 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
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基因功能參考文獻：
- Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. PMID: 29146595
- DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. PMID: 26429306
- this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. PMID: 24239607
- No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) PMID: 22664939
- Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. PMID: 22829930
- An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. PMID: 21536857
- Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. PMID: 20530286
- CLECSF6 is involved in the control of inflammation in neutrophils PMID: 14550269
- The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. PMID: 16360206
- Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. PMID: 17665455
- The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. PMID: 18258799
- The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. PMID: 18480830
- can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. PMID: 18541725
- DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. PMID: 19028959
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亞細胞定位：Cell membrane; Single-pass type II membrane protein; Extracellular side.
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組織特異性：Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood le
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