CLEC4A Antibody

說明書

中文名稱：

CLEC4A兔多克隆抗體
貨號：

CSB-PA016840
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA016840(CLEC4A Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA016840(CLEC4A Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 12+15%SDS-PAGE, Lysate: 40 μg, Lane 1-4: RAW264.7, Hela cells, 823 cells, A549 cells, Primary antibody: CSB-PA016840(CLEC4A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UMR7
基因名：

CLEC4A
別名：

C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody; C type lectin antibody; C type lectin DDB27 antibody; C type lectin superfamily 6 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 6 antibody; C-type lectin superfamily member 6 antibody; C-type lectin DDB27 antibody; C-type lectin domain family 4 member A antibody; C-type lectin domain family 4; member A antibody; C-type lectin domain family 4; member a2 antibody; C-type lectin superfamily member 6 antibody; CLC4A_HUMAN antibody; Clec4a antibody; Clec4a2 antibody; CLECSF6 antibody; DCIR antibody; Dcir1 antibody; DDB27 antibody; Dendritic cell immunoreceptor antibody; HDCGC13P antibody; Lectin like immunoreceptor antibody; Lectin; C-type; superfamily member 6 antibody; Lectin-like immunoreceptor antibody; LLIR antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human CLEC4A
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
基因功能參考文獻：
1. Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. PMID: 29146595
2. DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. PMID: 26429306
3. this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. PMID: 24239607
4. No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) PMID: 22664939
5. Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. PMID: 22829930
6. An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. PMID: 21536857
7. Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. PMID: 20530286
8. CLECSF6 is involved in the control of inflammation in neutrophils PMID: 14550269
9. The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. PMID: 16360206
10. Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. PMID: 17665455
11. The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. PMID: 18258799
12. The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. PMID: 18480830
13. can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. PMID: 18541725
14. DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. PMID: 19028959
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein; Extracellular side.
組織特異性：

Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood le
數據庫鏈接：

HGNC: 13257

OMIM: 605306

KEGG: hsa:50856

STRING: 9606.ENSP00000229332

UniGene: Hs.504657

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