CDON Antibody
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中文名稱：CDON兔多克隆抗體
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貨號：CSB-PA242369
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規格：￥2024
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圖片：
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Immunofluorescence analysis of MCF-7 cells, using CDON antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CDON Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human CDON.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,IF
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推薦稀釋比：
Application Recommended Dilution IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
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基因功能參考文獻：
- We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
- CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
- These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
- Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
- Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
- We found that CDON is overexpressed in prostate cancer PMID: 21849809
- CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
- Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
- CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
- CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
- Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190
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相關疾病：Holoprosencephaly 11 (HPE11)
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亞細胞定位：Cell membrane; Single-pass membrane protein.
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數據庫鏈接：
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