CBY1 Antibody

中文名稱：

CBY1兔多克隆抗體
貨號：

CSB-PA896889LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: U87 whole cell lysate, NTERA-2 whole cell lysate, K562 whole cell lysate
All lanes: CBY1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 kDa
Observed band size: 35 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CBY1 Polyclonal antibody
Uniprot No.：

Q9Y3M2
基因名：

CBY1
別名：

ARPP-binding protein antibody; C22orf2 antibody; CBY antibody; Cby1 antibody; CBY1_HUMAN antibody; Cytosolic leucine rich protein antibody; Cytosolic leucine-rich protein antibody; Golgi and endoplasmic reticulum-associated 1 antibody; HRIHFB2025 antibody; PIGEA 14 antibody; PIGEA-14 antibody; PKD2 interactor antibody; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 antibody; Protein Chibby antibody; Protein chibby homolog 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein chibby homolog 1 protein (41-126AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CBY1 Antibody (CSB-PA896889LA01HU)，的標記方式是Non-conjugated。對于CBY1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA896889LB01HU	CBY1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896889LC01HU	CBY1 Antibody, FITC conjugated
Biotin	CSB-PA896889LD01HU	CBY1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
基因功能參考文獻：
1. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. PMID: 27528616
2. chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. PMID: 28107095
3. Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. PMID: 27082063
4. CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. PMID: 26147002
5. Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. PMID: 25175341
6. the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation PMID: 24339928
7. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. PMID: 23707389
8. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. PMID: 23645032
9. C-terminal polycystin-2 influences the interaction with PIGEA14 PMID: 23838289
10. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
11. The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. PMID: 21182262
12. Chibby and clusterin were co-immunoprecipitated with NBPF1. PMID: 20096688
13. These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. PMID: 19940019
14. Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin PMID: 12712206
15. PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2 PMID: 15194699
16. As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis. PMID: 15245581
17. Chibby is not likely to promote colorectal carcinoma tumor development or progression. PMID: 16570344
18. CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. PMID: 17403895
19. intrinsically disordered TC-1 interacts with Cby via its transient helical structure PMID: 17905836
20. 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. PMID: 18573912
21. genes including CHIBBY involved in pediatric ependymomas. PMID: 18663750
22. Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. PMID: 19435523
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亞細胞定位：

Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans-Golgi network.
蛋白家族：

Chibby family
組織特異性：

Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
數據庫鏈接：

HGNC: 1307

OMIM: 607757

KEGG: hsa:25776

STRING: 9606.ENSP00000216029

UniGene: Hs.334911

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