CBY1 Antibody
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中文名稱：CBY1兔多克隆抗體
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貨號：CSB-PA068175
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA068175(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA068175(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：CBY1
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別名：ARPP-binding protein antibody; C22orf2 antibody; CBY antibody; Cby1 antibody; CBY1_HUMAN antibody; Cytosolic leucine rich protein antibody; Cytosolic leucine-rich protein antibody; Golgi and endoplasmic reticulum-associated 1 antibody; HRIHFB2025 antibody; PIGEA 14 antibody; PIGEA-14 antibody; PKD2 interactor antibody; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 antibody; Protein Chibby antibody; Protein chibby homolog 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human CBY1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
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基因功能參考文獻：
- FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. PMID: 27528616
- chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. PMID: 28107095
- Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. PMID: 27082063
- CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. PMID: 26147002
- Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. PMID: 25175341
- the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation PMID: 24339928
- Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. PMID: 23707389
- Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. PMID: 23645032
- C-terminal polycystin-2 influences the interaction with PIGEA14 PMID: 23838289
- Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
- The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. PMID: 21182262
- Chibby and clusterin were co-immunoprecipitated with NBPF1. PMID: 20096688
- These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. PMID: 19940019
- Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin PMID: 12712206
- PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2 PMID: 15194699
- As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis. PMID: 15245581
- Chibby is not likely to promote colorectal carcinoma tumor development or progression. PMID: 16570344
- CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. PMID: 17403895
- intrinsically disordered TC-1 interacts with Cby via its transient helical structure PMID: 17905836
- 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. PMID: 18573912
- genes including CHIBBY involved in pediatric ependymomas. PMID: 18663750
- Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. PMID: 19435523
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亞細胞定位：Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans-Golgi network.
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蛋白家族：Chibby family
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組織特異性：Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
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數據庫鏈接：
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