CBX2 Antibody

說明書

中文名稱：

CBX2兔多克隆抗體
貨號：

CSB-PA070046
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14781
基因名：

CBX2
別名：

Cbx 2 antibody; CBX2 antibody; CBX2_HUMAN antibody; CDC A6 antibody; CDCA6 antibody; Cell division cycle associated 6 antibody; Cell division cycle associated6 antibody; chromobox homolog 2 (Pc class homolog, Drosophila) antibody; Chromobox homolog 2 antibody; Chromobox homolog2 antibody; Chromobox protein homolog 2 antibody; hromobox homolog 2 antibody; M33 antibody; M33 polycomb like antibody; MOD 2 antibody; MOD2 antibody; Modifier 3 antibody; Modifier3 antibody; Pc class homolog antibody; Polycomb antibody; SRXY5 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human CBX2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
基因功能參考文獻：
1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management. PMID: 29998616
2. These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes. PMID: 28992316
3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2. PMID: 26431491
4. up-regulated in metastatic castration-resistant prostate cancer and elevated expression correlates with poor clinical outcome PMID: 26877821
5. CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway. PMID: 25569159
6. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast PMID: 25225902
7. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development. PMID: 23219007
8. Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex. PMID: 22419124
9. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
10. hPc2 serves as a SUMO E3 ligase for cystathionine beta-synthase, increasing the efficiency of sumoylation. PMID: 19107218
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相關疾病：

46,XY sex reversal 5 (SRXY5)
亞細胞定位：

Nucleus. Chromosome.
數據庫鏈接：

HGNC: 1552

OMIM: 602770

KEGG: hsa:84733

STRING: 9606.ENSP00000308750

UniGene: Hs.368410

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