BCLAF1 Antibody

說明書

中文名稱：

BCLAF1兔多克隆抗體
貨號：

CSB-PA001060
規格：

￥1090
圖片：
Western Blot analysis of A549 cells using BTF Polyclonal Antibody

Western Blot analysis of NIH-3T3 cells using BTF Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NYF8
基因名：

BCLAF1
別名：

Bcl 2 associated transcription factor antibody; Bcl-2-associated transcription factor 1 antibody; BCL2 associated transcription factor 1 antibody; BCLAF1 antibody; BCLF1_HUMAN antibody; bK211L9.1 antibody; Btf antibody; KIAA0164 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human BTF.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
基因功能參考文獻：
1. LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). PMID: 28864293
2. Results indicate a role for the RNA processing factors THRAP3 and BCLAF1 in the regulation of the cellular DNA damage response (DDR) pathway. PMID: 29112714
3. findings link treatment responsiveness to re-instatement of miR-194-5p/BCLAF1 balance PMID: 28216661
4. SMYD3 physically interacts with the promoter of BCLAF1 and upregulates its expression by accumulating di- and trimethylation of H3K4 at the BCLAF1 locus. BCLAF1 depletion inhibits SMYD3-induced autophagy. PMID: 26676636
5. The Bclaf1 can interact with the leucine zipper region of C/EBPbeta and cooperate with C/EBPbeta to upregulate IL-8. PMID: 26794446
6. both cytoplasmic BCLAF1 expression and nuclear BCLAF1 expression are increased in post-neoadjuvant therapy rectal cancer, and that negative and weak nuclear BCLAF1 expression are independently associated with a poor prognosis PMID: 26183150
7. SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells PMID: 25091051
8. BTF has functions distinct from TRAP150 in regulating the subcellular distribution of mRNAs in human cells. PMID: 23778535
9. BCLAF1 co-localized with gammaH2AX foci in nuclei and stabilized the Ku70/DNA-PKcs complex therein, facilitating non-homologous end joining (NHEJ)-based DSB repair in surviving cells. PMID: 22833098
10. In the absence of BclAF1 neutralization, viral gene expression and replication are inhibited. These data identify two temporally and mechanistically distinct functions used by human cytomegalovirus to down-regulate a cellular antiviral protein PMID: 22645331
11. Sirt1 negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1 PMID: 21454709
12. Findings indicate a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism. PMID: 20661537
13. Two-dimensional differential in-gel electrophoresis (2D-DIGE) revealed the differential expression of 51 proteins in response to C16-ceramide. Cell death-promoting factor Btf was found to be implicated in the apoptotic signal triggered by ceramide. PMID: 19705920
14. These results suggest that Btf localization is regulated by apoptotic signals, and that loss of emerin binding to Btf may be relevant to muscle wasting in Emery-Dreifuss muscular dystrophy. PMID: 15009215
15. These findings provide evidence that activation of TP53 gene transcription by PKCdelta triggers TP53-dependent apoptosis in response to DNA damage. PMID: 17938203
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亞細胞定位：

Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
蛋白家族：

BCLAF1/THRAP3 family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 16863

OMIM: 612588

KEGG: hsa:9774

STRING: 9606.ENSP00000435210

UniGene: Hs.486542

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