BAIAP2L1 Antibody
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中文名稱：BAIAP2L1兔多克隆抗體
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貨號：CSB-PA794497
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HepG2 cells, using BAIAP2L1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) BAIAP2L1 Polyclonal antibody
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Uniprot No.：
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基因名：BAIAP2L1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human BAIAP2L1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
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基因功能參考文獻：
- Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology. PMID: 27278019
- IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38, and activation of small GTPases Rac1 and Cdc42. In addition, cells overexpressing IRTKS exhibited an increased polarity characterized by elongated cytoplasm and extensive lamellipodia at leading edges. PMID: 27693783
- Upregulation of BAIAP2L1 is associated with ovarian cancer. PMID: 26222696
- Lacking the Bin-Amphiphysin-Rvs (BAR) dimerization domain of BAIAP2L1. PMID: 25589496
- IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase PMID: 23693078
- Identification of a novel oncogenic FGFR3-BAIAP2L1 fusion protein in bladder cancer. PMID: 23175443
- These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells. PMID: 21887275
- data suggest Src-stimulated IRTKS phosphorylation is essential for its function in cell motility PMID: 21840312
- Results describe the NMR structure of insulin receptor tyrosine kinase substrate (IRTKS) SH3 domain in complex with a repeat from Escherichia coli-secreted protein F-like protein encoded on prophage U (EspF(U)). PMID: 21098279
- Study characterised IRTKS, which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac, and expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions. PMID: 17430976
- Screening of the mammalian SH3 proteome for the ability to bind EspF(U) identified the SH3 domain of insulin receptor tyrosine kinase substrate (IRTKS), a factor known to regulate the cytoskeleton. PMID: 19366662
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亞細胞定位：Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
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數據庫鏈接：
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