BAG5 Antibody

文獻引用 (1) 說明書

中文名稱：

BAG5兔多克隆抗體
貨號：

CSB-PA890743HA01HU
規格：

￥440
圖片：
Western blot
All lanes: BAG family molecular chaperone regulator 5 antibody at 2μg/ml
Lane 1: Mouse kidney tissue
Lane 2: Mouse brain tissue
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 52, 57 kDa
Observed band size: 52 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890743HA01HU at dilution of 1:100
其他：

產品詳情
產品評價
引用文獻
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BAG5 Polyclonal antibody
Uniprot No.：

Q9UL15
基因名：

BAG5
別名：

BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human BAG family molecular chaperone regulator 5 protein (1-447AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，BAG5 Antibody (CSB-PA890743HA01HU)，的標記方式是Non-conjugated。對于BAG5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA890743HB01HU	BAG5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA890743HC01HU	BAG5 Antibody, FITC conjugated
Biotin	CSB-PA890743HD01HU	BAG5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death De Snoo M L, et al,Cell Death & Disease,2019

產品評價

靶點詳情

功能：

Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
基因功能參考文獻：
1. BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
2. Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
3. High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
4. This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
6. BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
7. Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
8. BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
9. A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
10. We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
11. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737
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數據庫鏈接：

HGNC: 941

OMIM: 603885

KEGG: hsa:9529

STRING: 9606.ENSP00000338814

UniGene: Hs.5443

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