BAG5 Antibody, HRP conjugated
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中文名稱：BAG5兔多克隆抗體, HRP偶聯
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貨號：CSB-PA890743HB01HU
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規格：￥880
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其他：
產品詳情
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產品描述：
CUSABIO uses the recombinant human BAG5 protein (1-447AA) as the immunogen to immunize the rabbit to yield the anti-BAG5 antibody. This resulting polyclonal antibody occurs as an HRP-conjugated IgG. Its purity reaches up to 95% using protein G purified. It only shows reactivity with human BAG5 protein, which is frequently overexpressed in many types of human tumors. BAG5 overexpression is correlated with a poor prognosis. And it has been verified to recognize BAG5 protein in ELISA analysis.
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產品名稱：Rabbit anti-Homo sapiens (Human) BAG5 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human BAG family molecular chaperone regulator 5 protein (1-447AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
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基因功能參考文獻：
- BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
- Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
- High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
- This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
- BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
- BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
- Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
- BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
- A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
- We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
- Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737
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