Apoa1 Antibody

^{Rare Species}

中文名稱：

Apoa1兔多克隆抗體
貨號：

CSB-PA001913LA01RA
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat Heart tissue, Rat Liver tissue, Rat Spleen tissue, Rat Lung tissue, Rat Kidney tissue, Rat Brain tissue, Rat Stomach tissue
All lanes: Apoa1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Apoa1 Polyclonal antibody
Uniprot No.：

P04639
基因名：

Apoa1
別名：

Apoa1Apolipoprotein A-I antibody; Apo-AI antibody; ApoA-I antibody; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I antibody; ProapoA-I)] antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Apoa1 protein (19-259AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產品，Apoa1 Antibody (CSB-PA001913LA01RA)，的標記方式是Non-conjugated。對于Apoa1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001913LB01RA	Apoa1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001913LC01RA	Apoa1 Antibody, FITC conjugated
Biotin	CSB-PA001913LD01RA	Apoa1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
基因功能參考文獻：
1. both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics. PMID: 27881716
2. ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux PMID: 25305669
3. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. PMID: 24814947
4. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. PMID: 24155931
5. It maintains cholesterol homeostasis. PMID: 24117066
6. on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels PMID: 22253414
7. translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s). PMID: 11773045
8. ABCA1-dependent cholesterol mobilization to apoA-I increased new cholesterol synthesis, indicating depletion of the regulatory pool of hepatocyte cholesterol during HDL formation PMID: 14993246
9. The association of CLPP with microtubules is mediated by caveolin-1, induced by apoA-I and regulates intracellular cholesterol trafficking for assembly of cellular lipids to apoA-I-HDL. PMID: 16606364
10. Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells. PMID: 18457017
11. ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation. PMID: 18535924
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亞細胞定位：

Secreted.
蛋白家族：

Apolipoprotein A1/A4/E family
組織特異性：

Major protein of plasma HDL, also found in chylomicrons.
數據庫鏈接：

KEGG: rno:25081

STRING: 10116.ENSRNOP00000065206

UniGene: Rn.10308

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