AP1M1 Antibody

說明書

中文名稱：

AP1M1兔多克隆抗體
貨號：

CSB-PA863146ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: AP1M1 antibody at 1.43µg/ml
Lane 1: A375 whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: Hela whole cell lysate
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 50 kDa
Observed band size: 49 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA863146ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA863146ESR1HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AP1M1 Polyclonal antibody
Uniprot No.：

Q9BXS5
基因名：

AP1M1
別名：

Adaptor protein complex AP-1 mu-1 subunit antibody; Adaptor-related protein complex 1 mu-1 subunit antibody; AP-1 complex subunit mu-1 antibody; AP-mu chain family member mu1A antibody; Ap1m1 antibody; AP1M1_HUMAN antibody; AP47 antibody; CLAPM2 antibody; Clathrin adaptor protein AP47 antibody; Clathrin assembly protein complex 1 medium chain 1 antibody; Clathrin assembly protein complex 1 medium chain antibody; Clathrin assembly protein complex AP1 mu subunit antibody; Clathrin coat assembly protein AP47 antibody; Clathrin coat-associated protein AP47 antibody; CLTNM antibody; Golgi adaptor AP 1 47 kDa protein antibody; Golgi adaptor HA1/AP1 adaptin mu-1 subunit antibody; HA1 47 kDa subunit antibody; MU 1A antibody; Mu-adaptin 1 antibody; Mu1A-adaptin antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human AP-1 complex subunit mu-1 protein (1-160AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
基因功能參考文獻：
1. found 31 ORF9p interaction partners, among which was AP1M1, the mu subunit of the adaptor protein complex 1 (AP-1). AP-1 is a heterotetramer involved in intracellular vesicle-mediated transport and regulates the shuttling of cargo proteins between endosomes and the trans-Golgi network via clathrin-coated vesicles. PMID: 29793951
2. Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. PMID: 28743825
3. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B PMID: 25449265
4. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. PMID: 23678182
5. IRS-1 associates with mu1A of the ubiquitously expressed AP-1 complex through three protein interaction motifs. PMID: 23478262
6. Mu1A binding to the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes. PMID: 22301137
7. AP-1 mu1A is involved in the kAE1 trafficking of kidney alpha-intercalated cells PMID: 20833140
8. These data identify the micro subunit of AP-1 (micro1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with micro1. PMID: 18057255
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亞細胞定位：

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
蛋白家族：

Adaptor complexes medium subunit family
數據庫鏈接：

HGNC: 13667

OMIM: 603535

KEGG: hsa:8907

STRING: 9606.ENSP00000388996

UniGene: Hs.71040

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