ALX1 Antibody

中文名稱：

ALX1兔多克隆抗體
貨號：

CSB-PA624031LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: ALX1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA624031LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ALX1 Polyclonal antibody
Uniprot No.：

Q15699
基因名：

ALX1
別名：

ALX homeobox 1 antibody; ALX homeobox protein 1 antibody; ALX1 antibody; ALX1_HUMAN antibody; CART 1 antibody; CART-1 antibody; CART1 antibody; Cartilage homeoprotein 1 antibody; Cartilage paired class homeoprotein 1 antibody; FND3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ALX homeobox protein 1 protein (10-304AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ALX1 Antibody (CSB-PA624031LA01HU)，的標記方式是Non-conjugated。對于ALX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA624031LB01HU	ALX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA624031LC01HU	ALX1 Antibody, FITC conjugated
Biotin	CSB-PA624031LD01HU	ALX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1.
基因功能參考文獻：
1. According to our analysis, three proteins, namely aristaless-like homeobox1 isoform X1 (ALX1), major histocompatibility complex polypeptide-related sequence A (MICA), and uncharacterized protein C14orf105 isoform X12 were found to be potential markers for Opisthorchis viverrini (OV)- infection, as they were predominantly found in all OV-infected groups PMID: 29936472
2. Our study concludes that the splice site variant identified in the ALX1 gene causes mild form of Frontonasal dysplasia. PMID: 27324866
3. we identify critical roles of ALX1 in lung cancer development and progression PMID: 26722397
4. Knockdown of the CART1 gene significantly inhibited cell invasion and proliferation and induce cell cycle arrest in S phase. PMID: 27053613
5. we found that depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied. PMID: 25736924
6. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer PMID: 24081945
7. ALX1 upregulated expression of the key EMT regulator Snail (SNAI1) and that it mediated EMT activation and cell invasion by ALX1. PMID: 23288509
8. Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting. PMID: 20451171
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相關疾病：

Frontonasal dysplasia 3 (FND3)
亞細胞定位：

Nucleus.
蛋白家族：

Paired homeobox family
組織特異性：

Cartilage and cervix tissue.
數據庫鏈接：

HGNC: 1494

OMIM: 601527

KEGG: hsa:8092

STRING: 9606.ENSP00000315417

UniGene: Hs.41683

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