AFF1 Antibody

說明書

中文名稱：

AFF1兔多克隆抗體
貨號：

CSB-PA010201
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P51825
基因名：

AFF1
別名：

AF 4 antibody; AF 4 protein antibody; AF4 antibody; AF4-MLL antibody; AF4/FMR2 family member 1 antibody; AFF 1 antibody; AFF1 antibody; AFF1_HUMAN antibody; ALL1 fused gene from chromosome 4 antibody; ALL1-fused gene from chromosome 4 protein antibody; FEL antibody; MGC134969 antibody; MLL/AF4 antibody; MLLT2 antibody; myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 2 antibody; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2 antibody; PBM1 antibody; Pre B cell monocytic leukemia partner 1 antibody; Protein AF-4 antibody; Protein FEL antibody; Proto-oncogene AF4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human AF-4.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325
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相關疾病：

A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
亞細胞定位：

Nucleus.
蛋白家族：

AF4 family
數據庫鏈接：

HGNC: 7135

OMIM: 159557

KEGG: hsa:4299

STRING: 9606.ENSP00000378578

UniGene: Hs.480190

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