AFF1 Antibody

說明書

中文名稱：

AFF1兔多克隆抗體
貨號：

CSB-PA446654
規格：

￥2024
圖片：
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using AF4 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AFF1 Polyclonal antibody
Uniprot No.：

P51825
基因名：

AFF1
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from N-terminal of Human AF4.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325
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相關疾病：

A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
亞細胞定位：

Nucleus.
蛋白家族：

AF4 family
數據庫鏈接：

HGNC: 7135

OMIM: 159557

KEGG: hsa:4299

STRING: 9606.ENSP00000378578

UniGene: Hs.480190

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