ADAM8 Antibody, Biotin conjugated
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中文名稱：ADAM8兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA10259D0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ADAM8 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：A Disintegrin And Metalloproteinase domain 8 antibody; ADAM 8 antibody; ADAM 8 precursor antibody; ADAM metallopeptidase domain 8 antibody; Adam8 antibody; ADAM8 protein antibody; ADAM8_HUMAN antibody; CD 156 antibody; CD156 antibody; CD156a antibody; CD156a antigen antibody; Cell surface antigen MS2 antibody; Disintegrin and metalloproteinase domain-containing protein 8 antibody; Human leukocyte differentiation antigen antibody; Macrophage cysteine rich glycoprotein antibody; MGC134985 antibody; MS 2 antibody; MS2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Disintegrin and metalloproteinase domain-containing protein 8 protein (677-824AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Possible involvement in extravasation of leukocytes.
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基因功能參考文獻：
- Authors conclude that ADAM8 promotes early metastatic processes such as transendothelial migration by upregulation of MMP-9 and shedding of PSGL-1 from breast cancer cells. PMID: 28986926
- ADAM8 on leukocytes holds a proinflammatory function in acute lung inflammation by promoting alveolar leukocyte recruitment. PMID: 28596294
- miR-720 is elevated in serum of patients with ADAM8-high TNBC and, in a group with other miRNAs downstream of ADAM8, holds promise as a biomarker for early detection of or treatment response of ADAM8-positive triple-negative breast cancer PMID: 27039296
- ADAM8 causes temozolomide resistance in glioblastoma cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met PMID: 25825051
- ADAM8 promotes GC cell proliferation and invasion, and its expression is positively correlated with poor survival, indicating that it might be a promising target in GC therapy PMID: 26024798
- ADAM8 expression is associated with increased migration and invasiveness of pancreatic ductal adenocarcinoma cells. PMID: 25629724
- ADAM8 and endostatin play a role in osteosarcoma progression. PMID: 25481287
- Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells. PMID: 25010013
- Results show that ADAM8 is overexpressed in colorectal cancer and promotes cell growth. PMID: 25098630
- N-glycosylation is essential for processing, localization, stability, and activity of ADAM8. PMID: 25336660
- ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. PMID: 24147597
- ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue. PMID: 24375628
- High ADAM8 expression is associated with pancreatic adenocarcinoma. PMID: 24526468
- Data show that Cu2+-generated reactive oxygen species (ROS), human ADAM8, ADAM10, and ADAM17 are all capable of cleaving mouse PrP (MoPrP). PMID: 24247244
- ADAM8 was highly expressed in 54.3% of hepatocellular carcinoma patients. ADAM8 expression was closely associated with tumor size, histological differentiation, recurrence, metastasis, and stage. High levels of ADAM8 resulted in poor prognosis. PMID: 22878099
- We used immunohistochemistry to compare ADAM8 protein expression in HCC and normal liver tissues and further analyze the ADAM8 protein expression in 105 HCC cases. Studied knocked down expression of ADAM8 in HepG2 cells. PMID: 22965687
- ADAM8 was robustly expressed by airway granulocytes in lung sections from human asthma patients PMID: 23670189
- These findings suggest for the first time that ADAM8 is frequently overexpressed in human gliomas and is closely associated with poor clinical outcome. PMID: 21983884
- ADAM8 mRNA & protein were highly expressed in medulloblastoma tissues when compared with normal cerebellum. This correlated with advanced stage, aggressive type, undifferentiated tumor & decreased survival. PMID: 22959284
- High expression of ADAM8 is associated with hepatocellular carcinoma. PMID: 22941466
- Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis with osteosarcoma. PMID: 22215309
- variation in the ADAM8 gene may affect serum sADAM8 concentrations and the risk of myocardial infarction PMID: 21640993
- ADAM8 is both associated with PSGL-1 through the ezrin-radixin-moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor. PMID: 22229154
- gene expressions for ADAM8 and ADAM15 were notably lower in ascending aorta as compared with aortic dissection PMID: 21728902
- increased expression in allergic rhinitis PMID: 21679521
- It regulates onset of blood circulation. (review) PMID: 21077325
- ADAM8 is a promising candidate to be involved in atherosclerosis, and its 2662 T/G allelic variant significantly associates with advanced atherosclerotic lesion areas and myocardial infarction. PMID: 19575316
- ADAM8 and EGFR are overexpressed in non-small cell lung cancer. PMID: 18710625
- expression of truncated forms of ADAM8 by the lung cancer cells may result in the specific upregulation of their invasive and osteoclastogenic activities in the bone microenvironment PMID: 20453887
- Overexpression of ADAM8 is associated with lung cancer progression PMID: 15623614
- ADAM8 may contribute to the airway remodeling process that occurs with asthma progression. PMID: 17339047
- All these data support a potential relevant role for ADAM-8 in the function of neutrophils during inflammatory response. PMID: 17548643
- ADAM8 is overexpressed in pancreatic ductal adenocarcinoma, influences cancer cell invasiveness and correlates with reduced survival. PMID: 17979891
- ADAM8 may have a role as a hypoxia-dependent protein in the pathogenesis and evolution of pancreatic cancer PMID: 18566576
- ADAM8 might be a therapeutic target for allergic respiratory diseases. PMID: 18691140
- Autoactivation of ADAM8: a novel pre-processing step is required for catalytic activity. PMID: 18811590
- ADAM8 is up-regulated upon formation of multinuclear giant cells after HPIV2 induction. PMID: 19284887
- The structure, function & expression of ADAM8 and its role in asthma are reviewed. Review. PMID: 19397475
- Increasing trend for ADAM8 expression is associated with early to advanced stages of myelodysplastic syndrome. PMID: 19469654
- ADAM-8 as a fibronectinase in human osteoarthritis chondrocytes. PMID: 19714641
- the effects of pH on substrate cleavage by ADAM8 beyond autocatalysis PMID: 19766586
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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組織特異性：Expressed on neutrophils and monocytes.
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數據庫鏈接：
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