ACTG2 Antibody
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中文名稱：ACTG2兔多克隆抗體
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貨號：CSB-PA000812
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of COLO205 cells using Actin α3 Polyclonal Antibody -
Western Blot analysis of mouse-heart mouse-lung cells using Actin α3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：ACT antibody; ACTA3 antibody; ACTE antibody; ACTG2 antibody; ACTH_HUMAN antibody; Actin antibody; Actin gamma 2 smooth muscle enteric antibody; Actin gamma enteric smooth muscle antibody; Actin like protein antibody; ACTL3 antibody; ACTSG antibody; Alpha actin 3 antibody; Alpha-actin-3 antibody; Gamma 2 actin antibody; Gamma-2-actin antibody; gamma-enteric smooth muscle antibody; Smooth muscle gamma actin antibody; Smooth muscle gamma-actin antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the N-terminal region of Human Actin α3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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基因功能參考文獻：
- fetus with intestinal pseudo-obstruction heterozygous for p.R63G pathogenic variant (NM_001615.3 c.187C>G; rs864309491) in exon 3 PMID: 29072330
- Whole exome and Sanger sequencing revealed a pathogenic variant in the ACTG2 gene in 4 out of 28 probands with chronic intestinal pseudo-obstruction and megacystis. Moreover, a mutational hotspot in the ACTG2 gene was recognized. Genetic heterogeneity is evident. PMID: 28422808
- R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the intestinal and bladder smooth muscle filaments. PMID: 27007401
- ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner. PMID: 28385530
- Missense variants in ACTG2 were identified in the patients with either megacystis-microcolon-intestinal hypoperistalsis syndrome or intestinal pseudo-obstruction. PMID: 26813947
- A heterozygous missense variant in ACTG2 was identified that impaired actin polymerization in sporadic Megacystis microcolon intestinal hypoperistalsis syndrome. PMID: 26647307
- ACTG2 is expressed in a fraction of small intestinal neuroendocrine tumors, can inhibit cell growth in vitro, and is positively regulated by miR-145. PMID: 27107594
- Mutations within ACTG2 are associated with fetal megacystis in microcolon intestinal hypoperistalsis syndrome. PMID: 25998219
- Phenotypic spectrum of ACTG2 missense variants involved severe pathology in multiple smooth muscle-dependent organs including the biliary tract and the uterus in the family with visceral myopathy. PMID: 25782675
- gammaSMA expression in hepatocellular carcinoma is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells PMID: 26110787
- ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease. PMID: 24676022
- Two novel mutations in the ACTG2 gene, p.R178L and p.R178C, have been identified in two unrelated children with congenital distended bladder, microcolon, and intestinal hypoperistalsis (MMIHS). PMID: 24337657
- The R148S variant in ACTG2 as a cause of autosomal dominant familial visceral myopathy in one family. PMID: 22960657
- NOX4 and ROS have a role in myofibroblast differentiation and collagen and alpha-actin production of TGF- beta1-induced nasal polyp-derived fibroblasts. PMID: 22722757
- SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
- It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. PMID: 17009076
- TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. PMID: 17554369
- The insertion-deletion polymorphism in intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. PMID: 17934296
- MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053
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相關疾病：Visceral myopathy (VSCM)
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亞細胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：Actin family
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